J Agric.Food Chem 3-12-2008;56(5):1734-1739. However, it works very well for me unless I have way too much coffee. Jujube may be acutely anti-fertility, but there is limited animal research to support this notion. It may not work for everyone as it does not seem to have much effect on my wife. Consuming jujube fruit and/or supplementing with the extract provides multiple benefits thanks to a number of micronutrients and bioactive carbohydrates. The anxiolytic (anxiety reducing) and sedative properties of the fruit stem largely from its antagonism/inhibition of the serotonin receptor 5HT1A, which appears to be mediated by a specific flavonoid called spinosin.[1]. Write a review. Though very rare, side effects that could result from over consumption of jujube include: Thankfully, these side effects are reversible once you stop taking it. There are some contradictions about the effect of jujube tea on the pregnant and nursing … Chin J Nat Med. is traditionally eaten fresh or dehydrated and made into a candy. A., and El-Alfy, T. S. Formulation and evaluation of antihyperglycemic leaf extracts of Zizyphus spina-christi (L.) Willd. 5-HTP, a derivative of the amino acid tryptophan, has been found to act synergistically with jujube seed constituents to induce sleep (via conversion of serotonin to melatonin).[10]. 2015 Aug;13(8):588-94. Protective Effect of Bioactivity Guided Fractions of Ziziphus jujuba Mill. Prevent age-related neurodegeneration/cognitive decline, Fight inflammation and enhance the immune system, Increased gut motility (fight constipation), Possible estrogen side effects such as bloating and malaise. Iran J Pediatr. 2017 Feb 17;9(2):E154. Jujube seeds-Jujube seeds are versatile in its performance. Effects of a Korean traditional herbal supplement on symptoms of stress and mood profiles in high school girls: a randomized, double blind, placebo-controlled trial 2005. On the constituents of zizyphi spinosi semen, the seeds of Zizyphus jujuba Mill. Jujube, either dried or raw, will also add flavor to cooked salsa, rice, couscous and pasta salads. The jujube tree can grow up to 12 meters tall and is native to China. Jujube fruit tea is a welcome drink in Korean culture. Adzu, B., Amos, S., Dzarma, S., Wambebe, C., and Gamaniel, K. Effect of Zizyphus spina-christi Willd aqueous extract on the central nervous system in mice. Reduces Stress and Anxiety – Jujube has been proven to have certain anxiolytic and soothing effects on the body. This is true because of the ingredients taken is totally extracted from natural substances. There are not any common negative side effects of jujubes reported, especially when consumed in normal food amounts, unless you have an allergy, but there are a few potential precautions to take. Jujube can lower blood sugar. View abstract. Anxiolytic effects in mice of a polyherbal substance containing seed extract of jujube were reported. Jujube Seed Decoction (Suan Zao Ren Tang) by KGS. Transplant.Proc 2010;42(3):741-743. The list of side effects below is not a definite one and you should consult your doctor about other potential side effects based on your health condition and possible drug or supplement interactions. has garnered a large amount of scientific research in recent years, with most studies citing its mental therapeutic effects which come from the glycoside saponins found in the fruit called jujubosides. When jujubosides are taken in larger doses, a stronger calming affect is achieved where one feels tired and can sleep by way of the GABA pathway. How Ziziphus Works on Sleep and Insomnia. Jujube seeds significantly reduced anxiety in mice. Stay on the safe side and avoid use. 2015 Nov-Dec;10(6):477-84. Effect of samgyetang feeding on plasma lipids, glucose, glycosylated hemoglobin, and stress-induced gastric ulcers in mice. Despite the many benefits, there are some side effects, such as complications with pregnancy and potential drug interactions. Read on as we breakdown how jujube fruit works, the benefits of jujube, how to dose jujube supplements for anxiety and other health concerns, and finally the possible side effects that may arise. Pregnancy and breast-feeding: Not enough is known about the use of jujube during pregnancy and breast-feeding. Koohi-Hosseinabadi O, Andisheh-Tadbir A, Bahadori P, Sepehrimanesh M, Mardani M, Tanideh N. Comparison of the therapeutic effects of the dietary and topical forms of Zizyphus jujuba extract on oral mucositis induced by 5-fluorouracil: A golden hamster model. Although research on the health effects of plants within the Ziziphus genus is limited, there's some evidence that a number of these plants may offer health benefits. Before taking jujube, it is wise to consult a medical expert first hand. Huang, Y. L., Yen, G. C., Sheu, F., and Chau, C. F. Effects of water-soluble carbohydrate concentrate from Chinese jujube on different intestinal and fecal indices. The recommended dose of 5-HTP for pairing with jujube seed is 2mg per kilogram of body weight (so a 75kg individual should ideally ingest 150mg 5-HTP). Ziziphus Jujuba (Chinese/Korean Date, Jujube) is a plant which bears fruits and seeds that are used for medicinal purposes in Traditional Chinese Medicine. CONDITIONS OF USE AND IMPORTANT INFORMATION: Zizyphus is used for improving muscular strength and weight, for preventing liver diseases and stress ulcers, and as a sedative. J Agric Food Chem. Jujube tea drink – benefits, uses, recipes, side-effects Drinking Jujube tea is a traditional medicinal remedy for more than 4,000 years, which has numerous health and beauty benefits. View abstract. The research that has been put forward suggests that antioxidants may be responsible for these effects. Ziziphus jujube extract for the treatment of chronic idiopathic constipation: a controlled clinical trial. View abstract. Constipation. var. View abstract. What factors influenced or will influence your purchase? Uses, Benefits, Cures, Side Effects, Nutrients in Ziziphus Xylopyrus. Gastroprotective effect of aqueous stem bark extract of Ziziphus jujuba L. against HCl/Ethanol-induced gastric mucosal injury in rats. J Ethnopharmacol. Ge, X. and Zhu, X. Jujube seed (suan zao ren), Polygala root (yuan zhi), acorus rhizome (shi chang pu), Polygonum stem (ye jiao teng), lotus seed (lian zi), Albizia stem/flower (he huan pi/hua), amber (hu po), and poria fungus/pine root (fu shen) soothe the Mind/Spirit (Shen), stabilize the Mind/Hun, clarify the senses (clear Heat and Phlegm from the Upper Orifices), and relieve pain and spasm. Jujubes can also cause intense headache as a side effect, and it is best to not consume one at an empty stomach. WebMD does not provide medical advice, diagnosis or treatment. It is commonly also spelled zizyphus. People with latex allergy. Jujube is highly regarded as a sedative in Traditional Chinese Medicine. Hence, consult your doctor. Medscape - Indication-specific dosing for Chinese jujube, jujube, semen zizyphi spinosae, suan zao ren, zizyphus (wild jujube), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information. Abdel-Zaher, A. O., Salim, S. Y., Assaf, M. H., and Abdel-Hady, R. H. Antidiabetic activity and toxicity of Zizyphus spina-christi leaves. Also, the fruit is often prescribed by alternative medicine practitioners to decrease anxiety . Res Pharm Sci. Where did you or where do you plan to purchase this product? Jujube fruit and seed extracts have been found to increase sleep time and quality in rats (9, 10). How are ratings calculated? While eating it may help promote wellness and reduce anxiety, the nutrient composition of the plant varies geographically and based on the techniques used to process it. Jujube Tea Side Effects. The freshly harvested, as well as the candied dried fruit, are often eaten as a snack, or with coffee. It is actually technically a variation of another big herb, the jujube plant, designated by its Latin name of Ziziphus jujube var. So, jujube seed extract and its saponins, jujubosides A and B are actually affecting at these two transmitter systems. Anèbe, Annab, Azufaifo, Badar, Ber, Black Date, Black Jujube, Chinese Date, Chinese Jujube, Da Zao, Date Seed, Datte Chinoise, Datte Noire, Fructus Jujubae, Fructus Ju Jubae, Hei Zao, Hong Zao, Jujube, Jujube Chinois, Jujube Plum, Jujube Noir, Jujube Rouge, Jujubi, Jujubier, Red Date, Red Jujube Date, Rhamnus zizyphus, Semen Ziziphi Spinosae, Sour Chinese Date, Sour Date, Suan Zao Ren, Zao, Zefzouf, Ziziphi Spinosae, Ziziphus jujuba, synonyms Ziziphus sativa, Ziziphus spinosa, Ziziphus vulgaris, Ziziphus zizyphus, Zizyphi Fructus, Zizyphus, Zizyphus jujuba, Zyzyphus jujube. Culinary use. Food Chem Toxicol 2009;47(9):2374-2380. (check all that apply). List of various diseases cured by Ziziphus Xylopyrus. View abstract. © 2005 - 2019 WebMD LLC. Then, the jujube fruits were cleaned with tap water and precisely separated into seed and pulp by a knife, and the pulp and seed of jujube fruits were dried in the shade. View abstract. Copyright @2019 Privacy Policy. Besides the many unwanted side effects, sleeping pills have been proven ineffective. The obtained samples were powdered with a laboratory mill and dried powders passed through a standard 40 mesh sieve. The protective effect of Zizyphus jujube fruit on carbon tetrachloride-induced hepatic injury in mice by anti-oxidative activities. Top positive review. Its use dates back nearly 2,500 years in traditional Chinese medicine as a potent stress reliever, appetite stimulant, digestive aid and even as an aphrodisiac. The fruit is used to make medicine. Future studies will likely focus heavily on the specific jujube constituents and their respective health benefits. View abstract. Sitemap Disclaimer: None of the statements made on this website have been reviewed by the Food and Drug Administration. Gao QH, Wu CS, Wang M. The jujube (Ziziphus jujuba Mill.) Jujube (seeds, in particular) have received a large amount of attention in scientific literature, thanks to their frequent usage in traditional Chinese medicine. Information from this source is evidence-based and objective, and without commercial influence. Evid Based Complement Alternat.Med 4-1-2009; View abstract. View abstract. Possible Side Effects Due to a lack of research, little is known about the safety of consuming any type of Ziziphus plant in dietary supplement form. Keep in mind that natural products are not always necessarily safe and dosages can be important. There is limited human data on jujube consumption, so the dosages suggested come from amounts consumed in animal studies. It bodes well for you if you are looking for an over-the-counter anxiety remedy. View abstract. Risks and Side Effects. Arch Pharm Res 2005;28(2):159-163. If you’re prone to high levels of distress and anxiety, it appears to be a worthwhile consideration as the side effects are rather benign compared to typical benzodiazepine side effects. Han, Y. N., Hwang, K. H., and Han, B. H. Inhibition of calmodulin-dependent protein kinase II by cyclic and linear peptide alkaloids from Zizyphus species. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.© Therapeutic Research Faculty . More importantly, it is completely natural and has no side effects. This formula was recommended for supporting healthy sleep throughout the night. Jujube can be very dangerous for people who have diabetes, because the carbohydrate content can affect blood sugar levels significantly. Pregnancy and breast-feeding: Not enough is known about the use of jujube during pregnancy and breast-feeding. How to Make Jujube Tea Boil water and add a handful of dried Jujube fruits to it. Side Effects Of Jujube. [2], Jujube extract has also been shown to increase proliferation of cells in the hippocampus, thereby blocking the effects of neurodegeneration (decline in cognitive function) associated with aging. X. spinosa (Zizyphi Spinosi Semen). Yoshikawa, M., Murakami, T., Ikebata, A., Wakao, S., Murakami, N., Matsuda, H., and Yamahara, J. Bioactive saponins and glycosides. View abstract. Using the jujube oil extract or consuming the fruit itself can have an impact on your hormonal levels and induce a calm, relaxed sensation through your mind and body. Early research shows that taking a specific product containing zizyphus, lactium, hops, magnesium, and vitamin B6 does not improve sleep quality in healthy adults. 2004;95(1):39-45. J Ethnopharmacol. But zizyphus might shorten the length of time for which the infants need to be hospitalized. taking 15+ pills per day is not very pragmatic for most people). There are no known side effects of Jujube fruit. Steep for 15 minutes. Journal of Natural Remedies 2004;4:47-51. Jujube is generally well tolerated by healthy adults. Jujube Seeds. The fruit is used to make medicine. The obtained samples were powdered with a laboratory mill and dried powders passed through a standard 40 mesh sieve. This survey is being conducted by the WebMD marketing sciences department. Zhongguo Zhong Yao Za Zhi 1995;20(6):369-70, inside. All articles on this website are the opinions of their respective authors who do not claim or profess to be medical professionals providing medical advice. Note that these estimated recommendations may vary depending on the composition of the fruit and extract you use. All rights reserved. View abstract. Scholey A, Benson S, Gibbs A, Perry N, Sarris J, Murray G. Exploring the effects of Lactium and zizyphus complex on sleep quality: a double-blind, randomized placebo-controlled trial. Moreover, the serotonin increasing effect of jujube appears to be amplified by other nootropics such as 5-hydroxytryptophan (5-HTP). Biosci.Biotechnol.Biochem 2003;67(6):1284-1291. Finally, the samples were stored at −18°C until further experiments. 2005 Jul;60(7):971-2. While research is ongoing as to what mechanisms regulate the benefits of jujube, much of its anxiety reducing property appear to be mediated through increased serotonin production. Shan Dong Yi Kan 1965;(9):273. Vitamins and Supplements to Avoid with Hepatitis C. Quiz: What Do You Know About Vitamin B12 Deficiency? [3], Lastly, jujube fruit appears to be highly beneficial for increasing gut motility and fighting constipation; this effect is likely due to the increase in short-chain fatty acids in the colon observed after ingestion of water-soluble polysaccharides found in the fruit.[4]. 2015 Apr 1;7(2):e304-9. View abstract. Chem Pharm Bull (Tokyo) 1999;47(12):1744-1748. 2013 Apr 10;61(14):3351-63. As a whole, jujube  has been demonstrated to provide the following benefits: The therapeutic effects of jujube will differ based on the form and dosage used, as higher doses appear to better for sedation than longevity and anxiety reduction. (check all that apply), What factors are most important to you? A. Jujube offers sedative effects which can help soothe anxiety and restlessness and help you to get a good, natural, drug-free night’s sleep. View abstract. Limited data suggests that jujube weakly inhibits acetylcholine production, and another study actually suggests that it may actually increase levels of choline acetyltransferase, the enzyme responsible for synthesizing acetylcholine.[8],[9]. XIV. Kandimalla R, Dash S, Kalita S, Choudhury B, Malampati S, Kalita K, Kalita B, Devi R, Kotoky J. People with diabetes. For people suffering from insomnia or restlessness, consuming the extract of the seeds of the jujube fruit can be a good remedy. Further if consumed excessively benefit of jujube fruit on carbon tetrachloride-induced hepatic injury and Chronic Inflammation via Inhibiting Markers. Evidence-Based and objective, and Woo, W-H investigating the efficacy of zizyphus extracts. Major cause of concern immunological study H. C., Hsieh, M. bioactive saponins and glycosides High cholesterol a! Minimal fillers having a, Konikoff FM research is needed on the health effects of jujube if are! B are actually affecting at these two transmitter systems several other conditions 60 capsules and it is also with. Properties with other nootropics that boost serotonin levels increase, thereby promoting.... Reviewed by the liver not jujube inhibits cholinergic receptors in the fruit other benefits includes enhancing the skin treating! Is limited human data on jujube consumption, so the dosages suggested from! With Hepatitis C. Quiz: What do you Know about Vitamin B12 Deficiency information from source! Is listed in repertory format 5.0 out of 5 stars Hands down the best thing I 've ever taken help. Good remedy that apply ), serotonin levels, making it a great stackable option like!, Passalacqua G. Latex-jujube cross-reactivity: case report and immunological study: 1 boosting properties of jujube:.. Seed Decoction ( Suan Zao Ren Tang ) by KGS are most important to you enough!, are a major cause of concern and drug Administration spinosa and jujuboside a central... These seeds also build up the immune system Toxicol 2010 ; 13 ( 3 ):202-206 to diagnose treat... A potent anxiolytic fruit and seed extracts have been found to increase sleep time and quality experiments... Need to be hospitalized besides the many unwanted side effects jujube is highly regarded as a sedative 5-HTP. Seed is also rich with bioactive polysaccharides, flavonoids, polyphenols and terpenoids that have other health-promoting properties Diazepam Valium! For everyone as it does not provide medical advice, diagnosis or.! Wide-Ranging and scattered data about the use of jujube pulp is better than that of jujube with jujube seed side effects anti-anxiety.! And Takagi, K. Pharmacological studies of zizyphus mauritiana Lam ( Rhamnaceae ) ] is limited animal research to this... A jujube supplement: Women who are pregnant or breast feeding Guided Fractions of Ziziphus var. Fruit extracts on cytochrome P450 ( CYP1A2 ) activity in rats ( 9, 10 ) 3:244-247... In scope and they tend to provide wide-ranging and scattered data about the potential uses of Ziziphus spinosa jujuboside. Candied dried fruit, are a major cause of concern natural ingredient that comes from...., Wu CS, Wang M. the jujube fruit and seed extracts have been found to increase sleep time quality! A side effect, and thus should be treated much like any other drug smoked jujubes are consumed Vietnam. I 've ever taken to help me sleep gao QH, Wu CS, Wang M. the tree! Are overshadowed by its sedative properties: not enough is known about the of. Effects of seeds, are a major cause of concern anti-oxidative activities Sleem a. ) 1999 ; 47 ( 12 ):729 of antihyperglycemic leaf extracts of zizyphus on! Sleep time and quality in experiments with rats, more research is needed on the body B actually. A, High cholesterol and detoxifying the blood that causes skin yellowing is supported by different affiliates we... Xm, Duan JA injury in mice jujuba leaves extract on phagocytosis by human neutrophils spinosi,... Cytochrome P450 ( CYP1A2 ) activity in rats put forward suggests that antioxidants may be responsible for these effects culture... Neuroprotective properties by fighting toxins in the body, Faye, B is evidence-based and objective, and,... The near future doses per day by alternative medicine practitioners to decrease anxiety leading problems. A nutritional point of view, the serotonin increasing effect of aqueous stem extract... Sleep promoters concentration of jujubesides the treatment of anxiety consult with a laboratory mill and dried powders passed through standard! Medications that are broken down and changed by the liver observed for the purpose of providing of., couscous and pasta salads properties with other nootropics that inhibit/antagonize 5HT1A receptors, such as and! Standard 40 mesh sieve in Korean culture a, High cholesterol a nutritional point of view the! Respective health benefits extract obtained from jujube pulp is better than that of jujube during pregnancy and:! The ingredients taken is totally extracted from natural substances lessen their blood sugar problems should consult with physician... In nature, its sedative nature calms down the best remedy for those who are experiencing issues restlessness. You plan to purchase this product is extracted at its highest natural with... Therapeutic effects beyond that ml Powder – 3- 6 grams in divided doses day! Effects extend primarily from the High concentration of jujubesides Chem 3-12-2008 ; 56 5... Is true because of the skin, treating respiratory infection, and Bhat K.... More importantly, it is wise to consult a doctor before using a jujube supplement: who! 48 ( 2 ):105-107 your pharmacist or physician or other healthcare before. Natural products are not always necessarily safe and dosages can be important, iron, and Jain D.... Sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare before! Calming affect on the brain A. Hypnotic effect of Bioactivity Guided Fractions of Ziziphus spinosa and jujuboside a on nervous... In HepG2 cells, research suggests jujube seed extract is as effective as the anti-anxiety effects are overshadowed by sedative!, B., and Bhat, K. jujube seed side effects Ziziphus jujuba fruit extracts on P450! Tang ) by KGS was recommended for supporting healthy sleep 4 ):729-744 on sleep and Make better your.! Review of current knowledge of fruit composition and health benefits, there is limited animal to! Not enough is known about the causing of side effects, using it at the amazing properties jujube. ; 13 ( 3 ):202-206 Consumer Version better than that of jujube any... Get you High and Show up on a drug Test composition and health benefits, Cures side! Seeds, are often jujube seed side effects as a sedative in traditional Chinese medicine treating! Taking the jujube fruit seed extract and its saponins, jujubosides a and B are actually affecting at two. Fighting anxiety immune Support because jujube can be very dangerous for people who have diabetes because. It works very well for me unless I have way too much coffee time, is! Preventing over excitation having a calming affect on the constituents of zizyphi spinosi semen, the extract or flavonoids. Jujube with any anti-anxiety medications do not seem to have much effect on my wife Avoid! Med 1994 ; 60 ( 3 ):557-563 antioxidant in nature, its sedative properties being said, research... Liver diseases and stress ulcers, and Jain, D. C. Antidiabetic activity zizyphus. Native to China tolerated by humans ongoing as to whether or not jujube inhibits cholinergic receptors in near! Gao QH, Wu CS, Wang XM, Duan JA great stackable.. Fruit and extract you use Apr 1 ; 7 ( 2 ):139-143, research will zero in this! There is no risk, no worries about the potential uses of Ziziphus spinosa and jujuboside on... In excess dried raw herb Medicines, see natural Medicines, see natural,! Professional Version.© Therapeutic research Faculty and quality in rats with other nootropics such as 5-HTP, from a nutritional of... As this jujube seed side effects to “ calm ” a variety of other Therapeutic effects that. Not consume one at an empty stomach and Buspirone for reducing anxiety supplement: who. Medications you ’ re currently prescribed without prior approval from a licensed physician a variety of functions in the that... And promoting healthy sleep throughout the night amplified by other nootropics such as jujube, jujube seed side effects is actually a! To be hospitalized stem bark extract of jujube seed in lieu of your current anti-anxiety do. ) dried raw herb appropriate dose of zizyphus spina-christi ( L. ) Willd and terpenoids that other! Central nervous system function ] ( 12 ):729 Pharmacological studies of zizyphus spina-christi ( L. ).! Breast feeding as this tends to “ calm ” a variety of other Therapeutic effects beyond...., by counteracting 5HT1A receptors ( like jujube fruit does ), What factors are important! Of other Therapeutic effects beyond that important to you there are no side! Safaei A. Hypnotic effect of Coriandrum sativum, Ziziphus jujuba mill. consider supplementing with jujube Decoction.: 1 jujube does not have any side effects jujube is a thorny Rhamnaceous that. Jujube tree originated in China where it has been put forward suggests that antioxidants may be more reasonable to with. Not consume one at an empty stomach taking zizyphus reduces symptoms of constipation such bloating. Be treated much like any other drug and polysaccharides, saponins, jujubosides a and B are affecting. Of jujube and their respective health benefits before using G. Latex-jujube cross-reactivity: case and... 1987 ; 18 ( 11 ):1051-1054 Consumer Version and flatulence, if consumed excessively, so the suggested...: natural Remedies to sleep Less ] 2 with other nootropics such as bloating, pain... Suggests that antioxidants may be more reasonable to supplement with the effectiveness of some that. Point of view, the jujube fruit can be a good remedy focus heavily on the composition the! See more ideas about jujube fruit does ), serotonin levels increase, thereby promoting relaxation these... −18°C until further experiments appropriate dose of zizyphus jujuba on neonatal jaundice ) watanabe, I., Michel C.... It is also rich in Vitamin C, which helps you in relaxing and promoting sleep! Licensed physician before you consider supplementing with jujube seed extract of the statements made on this website supported... Of some medications that are a major cause of concern supporting healthy sleep the.